Symbolic tolerance and sensitivity analysis of large scale electronic circuits

Available from British Library Document Supply Centre-DSC:DXN029693 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Target heterogeneity in oncology : the best predictor for differential response to radioligand therapy in neuroendocrine tumors and prostate cancer

Tumor or target heterogeneity (TH) implies presence of variable cellular populations having different genomic characteristics within the same tumor, or in different tumor sites of the same patient. The challenge is to identify this heterogeneity, as it has emerged as the most common cause of ‘treatment resistance’, to current therapeutic agents. We have focused our discussion on ‘Prostate Cancer’ and ‘Neuroendocrine Tumors’, and looked at the established methods for demonstrating heterogeneity, each with its advantages and drawbacks. Also, the available theranostic radiotracers targeting PSMA and somatostatin receptors combined with targeted systemic agents, have been described. Lu-177 labeled PSMA and DOTATATE are the ‘standard of care’ radionuclide therapeutic tracers for management of progressive treatment-resistant prostate cancer and NET. These approved therapies have shown reasonable benefit in treatment outcome, with improvement in quality of life parameters. Various biomarkers and predictors of response to radionuclide therapies targeting TH which are currently available and those which can be explored have been elaborated in details. Imaging-based features using artificial intelligence (AI) need to be developed to further predict the presence of TH. Also, novel theranostic tools binding to newer targets on surface of cancer cell should be explored to overcome the treatment resistance to current treatment regimens.http://www.mdpi.com/journal/cancerspm2021Nuclear Medicin

Presolar grains from meteorites: Remnants from the early times of the solar system

This review provides an introduction to presolar grains - preserved stardust from the interstellar molecular cloud from which our solar system formed - found in primitive meteorites. We describe the search for the presolar components, the currently known presolar mineral populations, and the chemical and isotopic characteristics of the grains and dust-forming stars to identify the grains' most probable stellar sources. Keywords: presolar grains, interstellar dust, asymptotic giant branch (AGB) stars, novae, supernovae, nucleosynthesis, isotopic ratios, meteoritesComment: 71 pages, 24 figures, 9 tables. Invited review. to appear in Chemie der Erd